Nimerta Rajwans

Nimerta Rajwans MSc is a Lab Manager at Sandra A. Rotman Laboratories, McLaughlin Rotman Centre for Global Health within the Translational Research Pillar.

The endothelium is the thin layer of cells that line the interior surface of blood vessels. They line the entire circulatory system, from the heart to the smallest capillary. During infection, endothelial cells can undergo a variety of changes that allow them to participate in the immune response. However, dysregulated endothelial activation appears to be a common pathogenic mechanism in conditions such as severe malaria and sepsis.  Nimerta's research involves using the HUVEC endothelial cell line as a model to investigate intracellular mechanisms of endothelial cell activation and to identify biological agents that can inhibit this process, with the ultimate aim of developing novel therapeutics.