Publications
2011
Peer-Reviewed Journals:
- Bhan A, Singh JA. The ethics of national tuberculosis programmes in low-income countries not rolling out Xpert MTB/RIF. Int J Tuberc Lung Dis. Nov 2011; 15(12): 1563.
- Tindana PO, Rozmovits L, Boulanger RF, Bandewar SVS, Aborigo RA, Hodgson AVO, Kolopack P, Lavery JV. Aligning community engagement with traditional authority structures in global health research: a case study from Northern Ghana. American Journal of Public Health. Aug 2011.
- Ali-Khan SE, Krakowski T, Tahir R, Daar AS. The use of race, ethnicity and ancestry in human genetic research. HUGO J. July 2011.
- Singer PA, Ansett S, Sagoe-Moses I. What could infant and young child nutrition learn from sweatshops? BMC Public Health. 2011; 11:276.
- Chakma J, Masum H, Perampaladas K, Heys J, Singer PA. Indian vaccine innovation: the case of Shantha Biotechnics. Globalization and Health. 2011; 7:9.
- Masum H, Batavia H, Bhogal N, Le K, Singer PA. Franchising rabies vaccine delivery: The case of Indian Immunologicals. PLoS Neglected Tropical Diseases. 2011; 5(4):e946.
- Masum H, Schroeder K, Khan M, Daar A. Open Source Biotechnology Platforms for Global Health and Development: Two Case Studies. Information Technologies & International Development. 2011; 7(1): 61-9.
- Batavia H, Chakma J, Masum H, Singer PA. Acumen Fund: Market-Minded Development. Stanford Social Innovation Review. 2011; Winter: 66-71.
- Emerson CI, Singer PA, Upshur REG. Access and use of human tissues from the developing world: ethical challenges and a way forward using a tissue trust. BMC Medical Ethics. 2011; 12: 2.
- Thorsteinsdóttir H, Ray M, Kapoor A, Daar AS. Health biotechnology innovation on a global stage. Nature Reviews Microbiology. 2011; 9: 137-43.
Book Chapters:
- Emerson CI. "The Moral Case for Eradication" In: S. L. Cochi and W. R. Dowdle, ed. Disease Eradication in the 21st Century: Implications for Global Health. Strüngmann Forum Report, vol. 7, J. Lupp, series ed. Cambridge, MA: MIT Press. p.103-113.
- Thompson KM, Rabinovich R, Conteh L, Emerson CI, Hall F, Singer PA, Vijayaraghavan M, Walker DG. "Group Report: Developing an
Eradication Investment Case" In: S. L. Cochi and W. R. Dowdle, ed. Disease Eradication in the 21st Century: Implications for Global Health. Strüngmann Forum Report, vol. 7, J. Lupp, series ed. Cambridge, MA: MIT Press. p.133-148.
http://mitpress.mit.edu/catalog/item/default.asp?ttype=2&tid=12685
2010
Peer-Reviewed Journals:
- El Zahabi-Bekdash, Lavery JV. Achieving precaution through effective community engagement in research with genetically modified mosquitoes. AsPac J Mol Biol Biotechnol. 2010; 18(2): 247-50.
- Simiyu K, Daar AS and Singer PA. Stagnant Health Technologies in Africa. Science. 2010; 330: 1483-4.
- Juma C. African health innovation systems: preface. BMC Int Health Hum Rights. 2010; 10(Suppl1): I1.
- Al-Bader S, Masum H, Simiyu K, Daar AS, Singer PA. Science-based health innovation in sub-Saharan Africa. BMC Int Health Hum Rights. 2010; 10(Suppl1): S1.
- Al-Bader S, Daar AS, Singer PA. Science-based health innovation in Ghana: health entrepreneurs point the way to a new development path. BMC Int Health Hum Rights. 2010; 10(Suppl1): S2.
- Simiyu K, Daar AS, Hughes M, Singer PA. Science-based health innovation in Rwanda: unlocking the potential of a late bloomer. BMC Int Health Hum Rights. 2010; 10(Suppl1): S3.
- Shah R, Singer PA, Daar AS. Science-based health innovation in Tanzania: bednets and a base for invention. BMC Int Health Hum Rights. 2010; 10(Suppl1): S4.
- Kamunyori S, Al-Bader S, Sewankambo N, Singer PA, Daar AS. Science-based health innovation in Uganda: creative strategies for applying research to development. BMC Int Health Hum Rights. 2010; 10(Suppl1): S5.
- Masum H, Shah R, Schroeder K, Daar AS, Singer PA. Africa’s largest long-lasting insecticide-treated net producer: lessons from A to Z Textiles. BMC Int Health Hum Rights. 2010; 10(Suppl1): S6.
- Chakma J, Masum H, Singer PA. Can incubators work in Africa? Acorn Technologies and the entrepreneur-centric model. BMC Int Health Hum Rights. 2010; 10(Suppl1): S7.
- Masum H, Singer PA. Venture capital on a shoestring: Bioventures’ pioneering life sciences fund in South Africa. BMC Int Health Hum Rights. 2010; 10(Suppl1): S8.
- Manveen P, Masum H, Heys J, Singer PA. Harnessing biodiversity: the Malagazy Institute of Applied Research (IMRA). BMC Int Health Hum Rights. 2010; 10(Suppl1): S9.
- Simiyu K, Masum H, Chakma J, Singer PA. Turning science into health solutions: KEMRI’s challenges as Kenya’s health product pathfinder. BMC Int Health Hum Rights. 2010; 10(Suppl1): S10.
- Perampaladas K, Masum H, Kapoor A, Shah R, Daar AS, Singer PA. The road to commercialization in Africa: lesson from developing the sickle-cell drug Niprisan. BMC Int Health Hum Rights. 2010; 10(Suppl1): S11.
- Masum H, Chakma J, Simiyu K, Ronoh W, Daar AS, Singer PA. Venture funding for science-based African health innovation. BMC Int Health Hum Rights 2010; 10(Suppl1): S12.
- McMahon DS, Singer PA, Daar AS, Thorsteinsdóttir H. Regenerative medicine in Brazil: small but innovative. Regen Med. 2010; 5(6): 863-76.
- Ali-Khan SE, Daar AS. Admixture mapping: from paradigms of race and ethnicity to population history. HUGO Journal. 2010; doi 10.1007/s11568-010-9145-y.
- Bandewar S, Kimani J, Lavery JV. The origins of a research community in the Majengo observational cohort study, Nairobi, Kenya. BMC Public Health. 2010; 10: 630.
- Rezaie R, Singer PA. Global health or global wealth? Nature Biotechnology 2010; 28: 907-9.
- Bhattacharyya O, Khor S, McGahan A, Dunne D, Daar AS, Singer PA. Innovative health service delivery models in low and middle income countries - what can we learn from the private sector? Health Research Policy and Systems. 2010; 8: 24.
- Singh JA, Daar AS, Singer PA. Shared principles of ethics for infant and young child nutrition in the developing world. BMC Public Health. 2010; 10: 321.
- Thorsteinsdottir H, Melon CC, Ray M, Chakkalackal S, Li M, Cooper JE, Chadder J, Saenz TW, de Souza Paula MC, Ke W, Li L, Madkour MA, Aly S, El-Nikhely N, Chaturvedi S, Konde V, Daar AS, Singer PA. South-South entrepreneurial collaboration in health biotech. Nature Biotechnology. 2010; 28(5): 407-16.
- McMahon DS, Thorsteinsdottir H, Singer PA, Daar AS. Cultivating regenerative medicine innovation in China." Regenerative Medicine. 2010; 5(10): 35-44.
- Masum H, Ranck J, Singer PA. Five promising methods for health foresight. Foresight Journal. 2010; 12(1): 54-66.
- Silver KL, Zhong K, Leke RGF, Taylor DW, Kain KC. Dysregulation of angiopoietins is associated with placental malaria and low birth weight. PLoS ONE. 2010; 5(3): e9481.
- Kass N, Ijsselmuiden C, Sewankambo N, Lavery JV. Evolving values in ethics and global health research. Global Public Health. 2010; 5(2): 154-63.
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Finney C, Lu Z, Hawkes M, Yeh W, Liles WC, Kain K. Divergent roles of IRAK4-mediated innate immune responses in two experimental models of severe malaria. Am J Trop Med Hyg. 2010; 83(1): 69-74.
- Emerson CI and Singer PA. Is there an ethical obligation to complete polio eradication? The Lancet. 2010; 375: 1340-1.
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Tansey CM, Herridge MS, Heselgrave R, Lavery JV. A framework for research ethics review during public emergencies. Canadian Medical Association Journal. 2010; 182(14): 1533-7.
- Thorsteinsdottir H., Melon CC, Ray M, Chakkalackal S, Li M, Cooper JE, Chadder J, Saenz TW, de Souza Paula MC, Ke W, Li L, Madkour MA, Aly S, AdlyN, Chaturvedi S, Konde V, Daar AS, Singer PA. South-South entrepreneurial collaboration in health biotech: Boosting trade and innovation? 2010; 28: 407-16.
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Min-Oo G, Ayi K, Bongfen SE, Tam M, Radovanovic I, Gauthier S, Santiago H, Rothfuchs AG, Roffe E, Sher A, Mullick A, Fortin A, Stevenson MM, Kain KC, Gros P. Cysteamine, the natural metabolite of pantetheinase, shows specific activity against plasmodium. Exp Parasitol. 2010; 125(4): 315-24.
Reports:
- Daar AS. Vision of a personal genomics future. Review of book: "The Language of Life: DNA and the Revolution in Personalized Medicine" by Francis S Collins. Nature. 2010; 463: 298-9.
Editorials, Op-eds, Commentaries:
- McMahon D, Thorsteinsdottir H, Daar AS, Singer PA. China's recipe for stem cell success: the ying and yang of regenerative medicine research and therapy. Science Progress. 2010. Available at: http://www.scienceprogress.org/2010/02/china-stem-cell/
- McMahon D, Thorsteinsdottir H. Regulations are needed for stem cell tourism: insights from China. Am J Bioeth. 2010; 10(5): 34-6.
2009
Peer-Reviewed Journals:
- Perry TL, Pandey P, Grant JM, Kain KC. Severe atovaquone-resistant Plasmodium falciparum malaria in a Canadian traveler returned from the Indian subcontinent. Open Medicine. 2009; 3: 10-16.
- Ezezika OC, Younger NS, Lu J, Kaiser DA, Corbin ZA, Nolen BJ, Kovar DR, Pollard TD. Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin. J Biol Chem. 2009; 284(4): 2088-97.
- Lovegrove FE, Tangpukdee N, Opoka R, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC, Kain KC. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS ONE. 2009; 4: e4912.
- Conroy AM, Serghides L, Finney C, Owino SO, Kumar S, Gowda DC, Liles WC, Moore JM, Kain KC. C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: implications for placental malaria. PLoS ONE. 2009; 4: e4953.
- Melon CC, Ray M, Chakkalackal S, Michelle Li, Cooper JE, Chadder J, Ke W, Li L, Madkour MA, Aly S, Adly N, Chaturvedi S, Konde V, Daar AS, Singer PA, Thorsteinsdottir H. A Survey of South-North Health Biotech Collaboration. Nature Biotechnology. 2009; 27(3): 229-32.
- Sibbald SL, Singer PA, Upshur R and Martin DK, Priority setting: what constitutes success? A conceptual framework for successful priority setting. BMC Health Services Research. 2009; 9: 43.
- Ezezika OC, Thomas F, Daar AS, Lavery JV, Singer PA. A Social Audit Model for Agro-biotechnology Initiatives in Developing Countries: Accounting for Ethical, Social, Cultural, and Commercialization Issues. Journal of Technology Management & Innovation. 2009; 4(3): 24-33.
- Hyder AA, Dawson L, Bachani AM, Lavery JV. Moving from research ethics review to research ethics systems in low- and middle-income countries. Lancet. 2009; 373: 862-5.
- Helmers A, Gowda D, Liles WC, Kain KC. Statins fail to improve outcome in experimental cerebral malaria and potentiate TLR-mediated cytokine production by murine macrophages. Am J Trop Med Hyg. 2009; 81: 631-7.
- Singer PA, Daar AS. How biodevelopment can enhance biosecurity. Bulletin of the Atomic Scientists. 2009; 23-30.
- Faust HS, Bensimon CM, Upshur REG. The role of faith-based organizations in the ethical aspects of pandemic flu planning lessons learned from the Toronto SARS experience. Public Health Ethics. 2009; 2(1): 105-12.
- Pinto AD, Upshur RE. Global health ethics for students. Dev World Bioeth. 2009; 9(1): 1-10.
- Finney CAM, Lu Z, LeBourhis L, Philpot DJ, Kain KC. Disruption of NOD-like receptors alters inflammatory response to infection but does not confer protection in experimental cerebral malaria. Am J Trop Med Hyg. 2009; 80: 718-22.
- Visscher KL, Woolridge N, Jenkinson J, Kain KC. Effectiveness of timeline pacing as a post-production cueing strategy in an educational three-dimensional animation for undergraduate medical students; A randomized controlled trial. JBC. 2009; 35: E3-E9.
- Al-Bader S, Frew SE, Essajee I, Liu VY, Daar AS, Singer PA. Small but tenacious: South Africa's health biotech sector. Nature Biotechnology. 2009; 27(5): 427-45.
- Craven SH, Ezezika OC, Haddad S, Hall RA, Momany C, Neidle EL. Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1. Mol Microbiol. 2009; 72(4): 881-94.
- Serghides L, Patel S, Ayi K, Lu Z, Gowda C, Liles WC, Kain KC. Rosiglitazone modulates innate immune responses to Plasmodium falciparum and improves outcome in experimental cerebral malaria. J Infect Dis. 2009; 199(10): 1538-45.
- Emerson CI, Upshur REG, Daar AS. Empirical Bioethics Research in the Developing World: When the 'Is' is Close to an 'Ought''. Am J Bioeth. 2009; 9(6): 101-3.
- Ali-Khan SE, Daar AS, Shuman C, Ray PN, Scherer SW. Whole genome scanning: resolving clinical diagnosis and management amidst complex data. Pediatr Res. 2009; 66(4): 357-63.
- Upshur R, Singh J, Ford N. Apocalypse or redemption: responding to extensively drug-resistant tuberculosis. Bull World Health Organ. 2009; 87(6): 481-3.
- Lavery JV, Singer PA, Ridzon R. Singh JA. Slutsky AS, Anisko JJ, Buchanan D. In global health research, is it legitimate to stop clinical trials early on account of their opportunity costs? PLoS Med. 2009; 6(6): e 1000071.
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Cohen ER, O'Neill JM, Joffres M, Upshur RE, Mills E. Reporting of informed consent, standard of care and post-trial obligations in global randomized intervention trials: a systematic survey of registered trials. Dev World Bioeth. 2009; 9(2): 74-80.
- Daar AS, Nabel EG, Pramming SK, Anderson W, Beaudet A, Liu D, Katoch VM, Borysiewicz LK, Glass RI, Bell J. "The Global Alliance for Chronic Diseases." Science. 2009; 26(324): 1642-44.
- Pelley JL, Daar AS, and Saner MA. State of Academic Knowledge on Toxicity and Biological Fate of Quantum Dots. Toxicological Sciences. 2009; 112(2), 276-96. doi:10.1093/toxsci/kfp188
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Zada G, Sivakumar W, Fisback D, Singer PA, and Weiss MH. Significance of postoperative fluid dieresis in patients undergoing transsphenoidal surgery for growth hormone-secreting pituitary adenomas. J Neurosurg. 2009.
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Boggild A, Krudsood S, Serghides L, Patel S, Tangpukdee N, Looareesuwan L, Liles WC, Kain KC. PPAR agonists as Adjunctive Treatment of Plasmodium falciparum Malaria: A Randomized, Double Blind, Placebo-Controlled Trial. Clinical Infectious Diseases 2009; 49: 841-49. (Accompanied by an editorial and chosen as a F1000, Faculty of 1000 Medicine, a "Must Read" article).
- Ayi K, Liles WC, Gros P, Kain KC. Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro. J Infect Dis. 2009; 200(8): 1289-99.
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Erdman LK, Cosio G, Helmers AJ, Gowda DC, Grinstein S, Kain KC. CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria. Journal of Immunology 2009; 183: 6452-59.
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Singh JA. Using the courts to challenge irrational health research policies and administrative decisions. Acta Trop. 2009;112(Suppl 1): S76-9.
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Singh JA. Research and legal liability. Acta Trop. 2009; 112(Suppl 1): S71-5.
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Conroy AL, Lafferty EA, Lovegrove FE, Krudsood S, Tangpukdee N, Liles WC, Kain KC. Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. Malaria J. 2009; 8: 295.
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Frew SE, Liu VY, Singer PA. A business plan to help the global South in its fight against neglected diseases. Health Affairs. 2009; 28(6): 1760-73.
Non-Peer-Reviewed Journals:
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Erdman LK, Hawkes M, Kain KC. Molecular approaches for the diagnosis of malaria and the characterization of genetic markers of drug resistance. Chapter 46. In; Diagnostic Molecular Microbiology, eds. Persing, Tenover, Tang, Versalovic, Relman, Wilber and White. 3rd edition. ASM Press. 2009.
Book Chapters:
- Upshur R. "Overcoming the problem of calibration: Towards a scholarly agenda for research ethics" In: Fernando Lolas, ed. Dimensiones Ethicas de Las Regulaciones en Salud. Centro Interdisciplinario de Estudios en Bioetica Universidad de Chile. 2009 p. 61-74.
- Asheim B, Ayerbe C, Boadi RY, Bovenberg JA, Bubela T, Castle D, Caulfield T, Chaturvedi S, Cloutier LM, Daar AS, Durell K, Francis CW, Glass AJ, Gold ER, Holbrook JA, Ingham M, Inkster I, Isaac AG, Kieff FS, May C, Metais E, Mitkova L, Nunez FX, Oriel S, Park WG, Piper T, Sirois S, Sullivan PH, Sumikura K, Valentin F, and Zeller C. The Role of Intellectual Property Rights in Biotechnology Innovation. Edited by David Castle, Canada Research Chair in Science, Faculty of Arts and Faculty of Law, University of Ottawa, December 2009 496.
Reports:
Editorials, Op-eds, Commentaries:
- Singer PA. Is Canada Ready for Bioterrorism? The Globe and Mail, 4 January, 2009.
- Singer PA, Daar AS: The tragic test of a peace-loving man. National Post, 19 January, 2009.
- Singer PA, Daar AS: Gaza Heartbreak. Sunday Star. The Toronto Star, February 1, 2009.
- Singer PA. SARS and swine flu: Lessons from the last outbreak. The Globe and Mail, 28 April, 2009.
- Singer PA. Grading a pandemic. National Post, May 11, 2009.
- Thorsteinsdottir, H. and Ray, M. (2009). A Global Approach to Biotech. The Mark News, 25 September 2009.
Patents:
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K Kain, C Liles W, F Lovegrove. Angiopoientin -1 and -2 Biomarkers for infectious diseases that compromise endothelial integrity - WO Patent WO/2009/059,404, 2009 - wipo.int
2008
Peer-Reviewed Journals:
- Kamunyori S, Al-Bader S, Shah R, Simiyu K, Singer PA, Daar AS. Accelerating African Health Innovation. Africa Journal. 2008; 20-21.
- Singer PA, Daar AS, Al-Bader S, Shah R, Simiyu K, Wiley RE, Kanellis P, Pulandiran M, Heymann M. Commercializing African Health Research: Building Life Science Convergence Platforms. Global Forum Update on Research for Health. 2008; 5: 143-50.
- Rosenberg-Yunger ZRS, Daar AS, Singer PA, Martin DK. Healthcare sustainability and the challenges of innovation to biopharmaceuticals in Canada. Health Policy. 2008; 87(3): 359-68.
- Lander B, Thorsteinsdottir H, Singer PA, Daar AS. Harnessing stem cells for health needs in India. Cell Stem Cell. 2008; 3(1): 11-5.
- Seguin B, Hardy B, Singer PA, Daar AS. Human genomic variation initiatives in emerging economies and developing countries. Nature Reviews Genetics. 2008; 9(10): s3-s4.
- Seguin B, Hardy B, Singer PA, Daar AS. Genomics, public health, and developing countries: the case of the Mexican National Institute of Genomic Medicine (INMEGEN). Nature Reviews Genetics. 2008; 9(10): s5-s8.
- Hardy B, Seguin B, Singer PA, Mukerji M, Brahmachari SK, Daar AS. From diversity to delivery: the case of the Indian Genome Variation initiative. Nature Reviews Genetics. 2008; 9(10): s9-s13.
- Seguin B, Hardy B, Singer PA, Daar AS. Universal health care, genomic medicine and Thailand: investing in today and tomorrow. Nature Reviews Genetics. 2008; 9(10): s14-s18.
- Hardy B, Seguin B, Ramesar R, Singer PA, Daar AS. South Africa: from species cradle to genomic applications. Nature Reviews Genetics. 2008; 9(10): s19-s22.
- Hardy B, Seguin B, Goodsaid F, Jimenez-Sanchez G, Singer PA, Daar AS. The next steps for genomic medicine: challenges and opportunities for the developing world. Nature Reviews Genetics. 2008; 9(10): s23-s27.
- Rezaie R, Frew SE, Sammut SM, Maliakkal MR, Daar AS, Singer PA. Brazilian health biotech--fostering crosstalk between public and private sectors. Nature Biotechnology. 2008; 26(6): 627-44.
- Seguin B, Hardy B, Singer PA, Daar AS. "Genomic Medicine and Developing Countries: creating a Room of their own." Nature Reviews Genetics. 2008; 9(6): 487-93.
- Frew SE, Kettler HE, Singer PA. The Indian and Chinese Health Biotechnology Industries: Champions of global health? Health Affairs. 2008; 27(4): 1029-41.
- Cohen ERM, Masum H, Berndtson K, Saunders V, Hadfield T, Panjwani D, Persad DL, Minhas GS, Daar AS, Singh JA, Singer PA. Public engagement on global health challenges. BMC Public Health. 2008; 8(168): 1-8.
- Seguin B, Hardy B, Singer PA, Daar AS. Bidil: Recontextualizing the Race Debate. The Pharmacogenomics Journal. 2008; 8(3): 169-173.
- Frew SE, Sammut SM, Shore AF, Ramjist JK, Al-Bader S, Rezaie R, Daar AS, Singer PA. Chinese health biotech and the billion-patient market. Nature Biotechnology. 2008; 26: 37-53.
- Reeleder D, Goel V, Singer PA, Martin D. Accountability agreements in Ontario hospitals: Are they fair? Journal of Public Administration Research and Theory. 2008; 18: 161-75.
- Erdman LK, Kain KC. Molecular diagnostic and surveillance tools for global malaria control. Travel Med Infect Dis. 2008; 6: 82-99.
- Land WG, Gutmann T, Daar AS. Emerging Science, Emerging Ethical Issues: Who should Fund Innate Alloimmunity-Supressing Drugs? Acta Chir Belg, 2008, 108, 73-82.
- Bello A, Poduch E, Liu Y, Wei L, Crandall I, Wang X, Dyanand C, Kain KC; Pai E; Kotra L. Structure-Activity Relationships of C6-Uridine Derivatives Targeting Plasmodia Orotidine Monophosphate Decarboxylase. Journal of Medicinal Chemistry. 2008; 51:439-48.
- Silver KL, Liles WC, Kain KC. Endothelial activation and dysregulation: a common pathway to organ injury in infectious diseases associated with systemic inflammation. Drug Discovery Today: Disease Mechanisms 2008; 4: 215-22.
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Finney CAM, Liles WC, Kain KC. Severe Malaria and Host Response: Time for a Paradigm Shift in Therapeutic Strategies to Improve Clinical Outcome. Drug Discovery Today: Disease Mechanisms. 2008; 4: 207-14.
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Singh JA and Daar AS. The 20-year African biotech plan. Nature Biotech. 2008; 26(3): 272-4.
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Silva Diego S, Gibson JL, Sibbald R, Connolly E, Singer PA. Clinical ethicists perspectives on organizational ethics in health care organizations. J of Med Ethics, 2008; 34: 320-3. doi: 10.1136/jme.2007.020891.
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Rose G, Suh K, Kain KC, Le Saux N, McCarthy A. Atovaquone-proguanil resistance in imported falciparum malaria in a young child. Ped J Infect Dis. 2008; 27: 567-9.
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Lovegrove F, Pena-Castillo L, Liles WC, Hughes TR, Kain KC. Plasmodium falciparum shows transcriptional versatility within the human host. Trends in Parasitology. 2008; 24: 288-91.
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Fan E, Soong S, Kain KC, Detsky AS. Capillariasis. New Engl J Med. 2008; 359: 75-80.
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Erdman LK, Finney CAM, Liles WC, Kain KC. Inflammatory pathways in malaria infection: TLRs share the stage with other components of innate immunity. Molecular Biochem Parasitol 2008; 162: 105-11.
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L Erdman, KC Kain. Stimulation of Toll-like Receptor 2 by Plasmodium Falciparum Glycosylphospatidylinositols Enhances Macrophage Internalization of Parasitized and Uninfected Erythrocytes. Clinical & Investigative Medicine. 2008; 31(4) Supplement.
Book Chapters:
- Green RM, Donovan A, Jauss SA, Singer PA (Eds.). "Global Bioethics: Issues of Conscience for the Twenty-First Century". (Oxford University Press, 2009)
- Viens AM and Singer PA, "Introduction", in Peter A. Singer and A.M. Viens (eds.), Bioethics for Clinicians (Cambridge: Cambridge University Press, 2008).
- Tulsky J and Singer PA, Quality End of Life Care, in Peter A. Singer and A.M. Viens (eds.), Bioethics for Clinicians (Cambridge: Cambridge University Press, 2008).
- Tulsky J, Emmanuel L, Singer PA, Advance Care Planning, in Peter A. Singer and A.M. Viens (eds.), Bioethics for Clinicians (Cambridge: Cambridge University Press, 2008).
- Martin D and Singer PA, Priority Setting, in Peter A. Singer and A.M. Viens (eds.), Bioethics for Clinicians (Cambridge: Cambridge University Press, 2008.
- Wright L, Ross K, Daar AS. Organ Transplantation. In: Singer P, Viens A, eds. The Cambridge Text of Bioethics. Cambridge University Press. 2008. pp. 145-152. ISBN 978-0-521-87284-3.
- Greenwood H, Daar AS. Regenerative Medicine. In: Singer P, Viens A, eds. The Cambridge Text of Bioethics. Cambridge University Press. 2008. pp. 153-159. ISBN 978-0-521-87284-3.
- Daar AS. Introduction. "Genetics and Biotechnology". In: Singer P, Viens, A, eds. The Cambridge Text of Bioethics. Cambridge University Press. 2008. pp. 143-144. ISBN 978-0-521-87284-3.
- Daar AS, Bakdash T, Khitamy AB, "Islamic Bioethics for Physicians Practising in the West",. In: Singer P, Viens AM, eds. The Cambridge Text of Bioethics. Cambridge University Press. 2008. pp. 408-415. ISBN 978-0-521-87284-3
- Gibson J, Connolly E, Sibbald R, and Singer PA, "Organizational Ethics", in Peter A. Singer and A.M. Viens (eds.), Bioethics for Clinicians (Cambridge: Cambridge University Press, 2008).
- McKneally M and Singer PA, "Teaching bioethics to medical students and postgraduate trainees in the clinical setting", in Peter A. Singer and A.M. Viens (eds.), Bioethics for Clinicians (Cambridge: Cambridge University Press, 2008).
- Nixon S, Upshur R, Robertson A, Benatar S, Thompson A, Daar AS. Public Health Ethics. In Bailey T, Caulfield T, Ries NM, eds. Public Health Law and Policy in Canada. 2nd Edition. Markham: LexisNexis Butterworths (2008) pp: 37-59.
- Thorsteindottir H, Smith R, Daar AS, Singer P, (2008) A global public good's perspective on the promoting and financing of genomics in Mordini E., (ed): Ethics and Health in the Global Village, CIC Edizioni Internazionali, Rome: 193-209.
- Wright L, Cambell M, Daar AS. Ethics in Transplantation: Allotransplantation and Xenotransplantation. Kidney Transplantation Peter J. Morris, Stuart J. Knechtle, 6th Edition. Chapter 39. pp 694-708 (2008).
- Land WG, Guttmann T, Daar AS. Emerging Science, Emerging Ethical Issues: Who should Fund Innate Alloimmunity-Supressing Drugs?. In Weimar W, Bos MA, Busschbach J, eds. Organ Transplantation: Ethical, Legal and Psychosocial Aspects Towards a Common European Policy. PABST Science Publishers, 2008. pp. 516-528. ISBN 978-3-89967-415-6.
- Singer PA, Bhatt A, Frew SE, Greenwood H, Mackie JE, Panjwani D, Persad DL, Salamanca-Buentello F, Seguin B, Taylor AD, Thorsteinsdottir H, and Daar AS. "Harnessing Advanced Technologies for Global Health Equity" in Global Bioethics: Issues of Conscience for the Twenty-First Century eds. Ronald M. Green, Aine Donovan and Steven A. Jauss. 2008. Oxford University Press. 368 pages; ISBN13: 978-0-19-954659-6. ISBN10: 0-19-954659-2.
- Thorsteinsdottir H. (2008). The Role of the Health System in Biotechnology in Brazil and Cuba. In S. Matlin, A. de Francisco, L. Sunaram, H-S Faich and M Gehner (eds) Health Partnership Review. Global Forum for Health Research.
- Thorsteinsdottir H, (2008). Strategies de promotion de la genomique comme bien public mondial, 185-222. Le Sante et le Bien Commun B.M. Knopper et Y. Joly (eds). Droit, Biotechnologie et Societe. Les editions Themis.
Books:
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Singer PA (Editor in Chief) and Viens AM (Executive Editor), Cambridge textbook of Bioethics (Cambridge: Cambridge University Press, 2008).
Reports:
- Gold ER, Adams,WA, Bernier L, Bubela T, Cassivi L, Castle D, Cleret de Langavant G, Martin Cloutier L, Daar AS, Delerue H, Glass AJ, Henry E, Knowles L, Morin, J-F, Piper T and Smith PJD. Toward a New Era of Intellectual Property: From Confrontation to Negotiation - A Report by the International Expert Group on Biotechnology, Innovation and Intellectual Property(September 9, 2008). Available at SSRN: http://ssrn.com/abstract=1260099.
Editorials, Op-eds, Commentaries:
- Singer PA. Built from Scratch. National Post. 29 January, 2008.
Patents:
- MM Greenberg, KC Kain, WCW Chan. Method for detecting pathogens using microbeads conjugated to biorecognition molecules – WO Patent WO/2007/093043, 2008 - freepatentsonline.com
2007
Peer-Reviewed Journals:
- Singer PA. Motivating Action: Why should Canadian Physicians participate in research, education or patient care in the developing world? Canadian Family Physician. 2007; 53(11): 1849-51.
- Daar AS, Singer PA, Persad DL, Pramming SK, Matthews DR, Beaglehole R, Bernstein A, Borysiewicz LK, Colagiuri S, Ganguly N, Glass RI, Finegood DT, Koplan J, Nabel EG, Sarna G, Sarrafzadegan N, Smith R, Yach D, Bell J. Grand Challenges in Chronic Non-Communicable Diseases. Nature. 2007; 450: 494-6.
- Daar AS, Berndtson K, Persad DL, Singer PA. How can developing countries harness biotechnology to improve health? BMC Public Health. 2007; 7(346): 1-9.
- Masum H, Daar AS, Al-Bader S, Shah R, Singer PA. Accelerating Health Product Innovation in Sub-Saharan Africa. Innovations (MIT Press). 2007; 2(4): 151-71.
- Masum H, Singer PA. A Visual Dashboard for Moving Health Technologies From "Lab to Village". J of Medical Internet Research. 2007; 9(4): e32.
- Taylor AD, Brook D, Watters D, Dowdeswell E, Daar AS, Singer PA. North-South Partnerships A study of Canadian Firms. Nature Biotechnology. 2007; 25(9): 978-9.
- Singer PA, Berndtson K, Tracy CS, Cohen ERM, Masum H, Lavery JV, Daar AS. A tough transition. Nature. 2007; 449: 160-3.
- Singer PA, Taylor AD, Daar AS, Upshur REG, Singh JA, Lavery JV. (2007). Grand Challenges in Global Health: The Ethical, Social and Cultural Program. PLoS Med. 2007; 4(9): 1440-4.
- Berndtson K, Daid T, Tracy CS, Bhan A, Cohen ERM, Upshur REG, Singh JA, Daar AS, Lavery JV, Singer PA. Grand Challenges in Global Health: Ethical, Social, and Cultural issues based on key informant perspectives. PLoS Med. 2007; 4(9): 1445-50.
- Tindana PO, Singh JA, Tracy CS, Upshur REG, Daar AS, Singer PA, Frohlich J, Lavery JV. Grand Challenges in Global Health: Community Engagement in Research in Developing Countries. PLoS Med. 2007; 4(9): 1451-5.
- Bhan A, Singh JA, Upshur REG, Singer PA, Daar AS. Grand Challenges in Global Health: Engaging Civil Society Organization in Biomedical Research in Developing Countries. PLoS Med. 2007; 4(9): 1456-9.
- Frew SE, Rezaie R, Sammut SM, Ray M, Daar AS, Singer PA. India's home-grown health biotechnology sector at a crossroads. Nature Biotech. 2007: 25(4): 403-17.
- Thorsteinsdottir H, Daar AS, Singer PA. Innovation Cultures in Developing Countries: The Case of Health Biotechnology. Comparative Technology Transfer and Society. 2007; 5(2): 178-201.
- Singer PA, Court EB, Bhatt A, Frew SE, Greenwood H, Persad DL, Fabio Salamanca-Buentello F, Seguin B, Taylor AD, Thorsteinsdottir H, Daar AS. Applying genomics-related technologies for Africa's health needs. African J Med and Medical Sciences. 2007; 36 (Suppl): 7-14.
Book Chapters:
- Court E, Salamanca-Buentello F, Singer PA, Daar AS. "Nanotechnology and the Developing World. In: Nanotechnologies, Ethics and Politics. UNESCO (COMEST). Paris, France P 155.
- Seguin B, Essajee S, Dabu A, Jimenez-Sanchez G, and Daar AS. Implications of Human Genomic Variation Studies and Pharmacogenomics for Global Health. In "Pharmacogenomics in Admixed Populations" Medical Intelligence Unit, Landes Bioscience. 2007; 198-207.
- Court EB, Salamanca-Buentello F, Singer PA, Daar AS. Public Engagement and Education for Ethics in Nanotechnology. In "Nanotechnologies, Ethics and Politics. Ed. Henk Ten Have. UNESCO Ethics Series. ISBN 978-92-3-104051-1.
2006
Peer-Reviewed Journals:
- Greenwood HL, Singer PA, Downey GP, Martin DK, Thorsteinsdottir H, Daar AS. Regenerative medicine and the developing world. PLoS Med. 2006; 3(9): 1496-1500.
- Mackie JE, Taylor AD, Finegold DL, Daar AS, Singer PA. Lessons on ethical decision-making from the bioscience industry. PLoS Med. 2006; 3(5): 605-10.
- Wilson K, McDougall C, Upshur REG, the Joint Centre for Bioethics SARS Global Health Ethics Research Group (Daar AS, Singer PA, CS Tracy). The New International Health Regulations and the Federalism Dilemma. PLoS Med. 2006; 3(1): 30-4.
- Persad DL, Quach U, Thorsteinsdottir H, Salamanca-Buentello F, Singer PA, Daar AS. Enabling knowledge societies in developing countries: the example of genomics. Int J Biotech. 2006; 8(1/2): 4-22.
- Thorsteinsdottir H, Daar AS, Singer PA, Archambault E, Arunachalame S. Health biotechnology publishing takes-off in developing countries. Int J Biotech. 2006; 8(1/2): 23-42.
- Quach U, Thorsteinsdottir H, Renihan J, Bhatt A, Costa Von Aesch Z, Singer PA, Daar AS. Biotechnology patenting takes off in developing countries. Int J Biotech. 2006; 8(1/2): 43-59.
- Greenwood HL, Thorsteinsdottir H, Perry G, Renihan J, Singer PA, Daar AS. Regenerative medicine: new opportunities for developing countries. Int J Biotechn. 2006; 8(1/2): 60-77.
- Seguin B, State L, Singer PA, Daar AS. Scientific diasporas as an option for brain drain:Â re-circulating knowledge for development. Int J Biotech. 2006; 8(1/2): 78-90.
- Frew SE, Sammut SM, Siu WW, Daar AS, Singer PA. The role of the domestic private sector in developing countries for addressing local health needs. Int J Biotech. 2006; 8(1/2): 91-102.
- Mackie JE, Taylor AD, Daar AS, Singer PA. Corporate social responsibility strategies aimed at the developing world: perspectives from bioscience companies in the industrialised world. Int J Biotech. 2006; 8(1/2): 103-18.
- Dowdeswell E, PeSinger PA, Daar AS. Increasing human security through biotechnology. Int J Biotech. 2006; 8(1/2): 119-31.
- Dowdeswell E, Daar AS, Acharya T, Singer PA. Realising the promise of genomics: exploring governance. Int J Biotech. 2006; 8(1/2): 132-41.
- Singer PA, Daar AS, Salamanca-Buentello F, Court EB. Nano-Diplomacy. Georgetown J of Int Affairs. 2006; 129-37.
2005
Peer-Reviewed Journals:
- Dowdeswell E, Daar AS, Singer PA. Getting governance into genomics. Science and Public Policy. 2005; 32(6): 497-8.
- Benatar SR, Daar AS, Singer PA. Global Health Challenges: The need for an expanded discourse on bioethics. PLoS Med. 2005; 2(5): 587-9.
- Thorsteinsdottir H, Sa¡enz TW, Singer PA, Daar AS. Different rhythms of Health biotechnology development in Brazil and Cuba. J of Business Chemistry. 2005; 2(3): 99-106.
- Salamanca-Buentello F, Persad DL, Court EB, Martin DK, Daar AS, Singer PA. Nanotechnology and the Developing World. PLoS Med. 2005; 2(4): 300-3.
- Morel CM, Acharya T, Broun D, Dangi A, Elias C, Ganguly NK, Gardner CA, Gupta RK, Haycock J, Heher AD, Hotez PJ, Kettler HE, Keusch GT, Krattiger AF, Kreutz FT, Lall S, Lee K, Mahoney R, Martinez-Palomo A, Mashelkar RA, Matlin SA, Mzimba M, Oehler J, Ridley RG, Senanayake P, Singer PA, Yun M. Health innovation networks to help developing countries address neglected diseases. Science. 2005; 309: 401-4.
- Singer PA, Salamanca-Buentello F, Daar AS. Harnessing nanotechnology to improve global equity. Issues in Science and Technology. 2005; 57-64.
- Court EB, Daar AS, Persad DL, Salamanca-Buentello F, Singer PA. Tiny technologies for the global good. Nanotoday. 2005: 14-5.
- Breslin JM, MacRae SK, Bell J, Singer PA, The University of Toronto Joint Centre for Bioethics Clinical Ethics Group. Top 10 Health Care Ethics Challenges Facing the Public: Views of Toronto Bioethicists. BMC Med Ethics. 2005; 6: 5.
- Morel CM, Acharya T, Broun D, Dangi A, Elias C, Ganguly NK, Gardner CA, Gupta RK, Haycock J, Heher AD, Hotez PJ, Kettler HE, Keusch GT, Krattiger AF, Kreutz FT, Lall S, Lee K, Mahoney R, Martinez-Palomo A, Mashelkar RA, Matlin SA, Mzimba M, Oehler J, Ridley RG, Senanayake P, Singer PA, Yun M. Health innovation in developing countries to address diseases of the poor. Innovation Strategy Today. 2005; 1(1): 1-15.
- Daar AS, Singer PA. Pharmacogenetics and geographical ancestry: Implications for drug development and global health. Nature Reviews Genetics. 2005; 6: 241-6.
- Gibson JL, Martin DK, Singer PA. Evidence, economics and ethics: Resource allocation in health services organizations. Healthcare Quarterly. 2005; 8: 50-9.
- Acharya T, Abdur Rab M, Singer PA, Daar AS. Harnessing genomics to improve health in the Eastern Mediterranean Region - an executive course in genomics policy. Health Research and Policy Systems. 2005; 3(1): 1-9.
- Smith AC, Mugabe J, Singer PA, Daar AS. Harnessing genomics to improve health in Africa an executive course to support genomics policy. Health Research and Policy Systems. 2005; 3(2): 1-12.
Book Chapters:
- Daar AS, Singer PA. Harnessing Genomics for Global Health. In: Jones GA, McCarney P, Skolnik ML, eds. Creating Knowledge, Strengthening Nations: The Changing Role of Higher Education. Toronto: University of Toronto Press (2005).
- Daar AS, Acharya T, Filate I, Thorsteinsdóttir H, Singer PA. Beyond GM Foods: Genomics, Biotechnology and Global Health Equity. In: Thiele F, Ashcroft R, eds. Bioethics in a Small World. Berlin: Springer Verlag (2005).
- Singer PA, Panjwani D, Frew S, Greenwood H, Persad DL, Salamanca-Buentello F, Seguin B, Taylor AD, Thorsteinsdottir H, Daar AS, "The Role of Emergent Technologies in the Health of the Developing World". BiovisionAlexandria Proceedings (2005).
Peer-Reviewed Journals:
- Acharya T, Daar AS, Thorsteinsdottir H, Dowdeswell E, Singer PA. Strengthening the role of genomics in global health. PLoS Medicine. 2004; 1(3): 195-7.
- Merali Z, Singer PA, Boulyjenkov V, Daar AS. The ELSI Genetics Regulatory Resource Kit: A Tool for Policymakers in Developing Countries. Journal of Law, Medicine and Ethics. 2004; 32(3): 692-700.
- Raja AJ, Singer PA. Transatlantic divide in publication of content relevant to developing countries. BMJ. 2004; 329: 1429-30.
- Thorsteinsdottir H, Quach U, Martin DK, Daar AS, Singer PA. Introduction: Promoting global health through biotechnology: An exploration of health biotechnology innovation systems in developing countries. Nature Biotechnology. 2004; 22: DC3-7.
- Ferrer M, Thorsteinsdottir H, Quach U, Singer PA, Daar AS. The scientific muscle of Brazil's health biotechnology. Nature Biotechnology. 2004; 22: DC8-DC12.
- Zhenzhen L, Jiuchun Z, Ke W, Thorsteinsdottir H, Quach U, Singer PA, Daar AS. Health biotechnology in China - the reawakening of a giant. Nature Biotechnology. 2004; 22: DC13-DC18.
- Thorsteinsdottir H, Saenz TW, Quach U, Daar AS, Singer PA. Cuba - innovation through synergy. Nature Biotechnology. 2004; 22: DC19-DC24.
- Abdelgafar B, Thorsteinsdottir H, Quach U, Singer PA, Daar AS. The emergence of Egyptian biotechnology from generics. Nature Biotechnology. 2004; 22: DC25-DC30.
- Kumar NK, Quach U, Thorsteinsdottir H, Daar AS, Somsekhar H, Singer PA. Indian biotechnology - rapidly evolving and industry-led. Nature Biotechnology. 2004; 22: DC31-DC36.
- Motari M, Quach U, Thorsteinsdottir H, Martin DK, Daar AS, Singer PA. South Africa - blazing a trail for African biotechnology. Nature Biotechnology. 2004; 22: DC37-DC41.
- Wong J, Quach U, Thorsteinsdottir H, Singer PA, Daar AS. South Korean biotechnology - a rising industrial and scientific powerhouse. Nature Biotechnology. 2004; 22: DC42-47.
- Thorsteinsdottir H, Quach U, Daar AS, Singer PA. Conclusions: promoting biotechnology innovation in developing countries. Nature Biotechnology. 2004; 22: DC48-DC52.
- Acharya T, Kumar NK, Muthuswamy V, Daar AS, Singer PA. Harnessing genomics to improve health in India - an executive course to support genomics policy.â€Â Health Research and Policy Systems. 2004; 2: 1-13.
- Smith RD, Thorsteinsdottir H, Daar AS, Gold ER, Singer PA. Genomics knowledge and equity: a global public goods perspective of the patent system. Bull of the World Health Org. 2004; 8: 385-9.
2003
Peer-Reviewed Journals:
- Singer PA, Benatar SR, Bernstein M, Daar AS, Dickens BM, MacRae SK, Upshur REG, Wright L, Zlotnik Shaul R. Ethics and SARS: Learning Lessons from the Toronto Experience. BMJ. 2003; 327: 1342-4.
- Acharya T, Daar AS, Singer PA. Biotechnology and the UN’s millennium development goals. Nature Biotechnology. 2003; 21: 1434-6.
- Varmus H, Klausner R, Zerhouni E, Acharya T, Daar AS, Singer PA. Grand Challenges in Global Health. Science. 2003; 302: 398-9.
- Thorsteinsdottir H, Daar AS, Smith RD, Singer PA. Genomics - A Global Public Good? Lancet. 2003; 361: 891-2.
- Dowdeswell E, Daar AS, Singer PA. Bridging the Genomics Divide. Global Governance J. 2003; 9: 1-6.
- Mnyusiwalla A, Daar AS, Singer PA. Mind the Gap: Science and Ethics in Nanotechnology. Nanotechnology. 2003; 14: R9-13.
- Benatar SR, Daar AS, Singer PA. Global Health Ethics: The rationale for mutual caring. International Affairs. 2003; 79: 107-38.
2002
Peer-Reviewed Journals:
- Singh JA, Singer PA. Isolationism is not the answer to bioterrorism: Increased support for research in the developing world would be a better strategy. Nature. 2002; 420: 605.
- Daar AS, Thorsteinsdottir H, Martin DK, Smith AC, Nast S, Singer PA. Top 10 biotechnologies for improving health in developing countries. Nature Genetics. 2003; 32: 229-32.
2001
Peer-Reviewed Journals:
- Singer PA. Minimal refereeing will lead to global equity of information. BMJ. 2001; 323(7304): 111-2.
- Singer PA, Daar AS. Harnessing genomics and biotechnology to improve global health equity. Science. 2001; 294: 87-9.
- Singer PA, Benatar SR. Beyond Helsinki: A vision for global health ethics. BMJ. 2001; 322: 747-8.
- Benatar SR. The coming catastrophe in international health: an analogy with lung cancer. International Journal. 2001; LV1(4): 611-31.
- Benatar SR. South Africa's transition in a globalising world: HIV/AIDS as a window and a mirror. International Affairs. 2001; 77(2): 347-75.
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Benatar SR. Respiratory health in a globalising world. Amer J Resp & Crit Care Med. 2001; 163: 1064-7.


